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Treatment response should be tracked with redox proteomics (cysteine-switch/oxidized-PTP signatures), peroxiredoxin redox states (as sentinels of H 2 O 2 flux) and lipid-peroxide markers (F 2 -isoprostanes, oxidized phospholipids), enabling adaptive dosing that preserves beneficial redox signalling in normal tissues while exploiting malignant redox liabilities (Kisty et al

Before we dive into the specific differences, let's establish a baseline

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Paiva I, Cellai L, Meriaux C, Poncelet L, Nebie O, Saliou JM et al (2022) Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

The results show that in human skin explants, treatment with CG significantly reduces the percentage of cells with a high melanin content, which suggests a depigmentation effect, and that in explants irradiated with UVA/UVB, treatment with CG increases the levels of components of the dermal extracellular matrix, such as collagen type 1, elastin and sulfated GAGs, components that had decreased in irradiated explants

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