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Moreover, oxidative stress facilitates the abnormal aggregation and toxicity of neurodegenerative hallmark proteins such as -amyloid (A) and -synuclein, linking tinnitus pathophysiology to broader neurodegenerative processes (Boutt et al., 2021)

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Often used as a layered approach

Data synthesis The studies varied in terms intervention type, dosage regimens, duration of treatment, study design, and participant characteristics such as disease stage and concurrent medication hence given the substantial heterogeneity, a quantitative meta-analysis was not performed

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