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Collectively, these mechanistic insights indicate that incretin mimetics modulate central neuroimmune and bioenergetic pathways directly within neurons and microglia, providing a biological basis for their diseasemodifying potential in neurodegenerative disorders

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CDA-HFD study CDA-HFD mice were randomly allocated to groups and treated with vehicle or semaglutide 20 g kg 1 ( n = 15) for 6 weeks or 12 weeks