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The lower FI observed at pH 5, 7, and 9 suggest a less compact protein structure, where aromatic and hydrophobic residues are far apart and engaged in more interactions with the hydrophilic environment (Du et al., 2022)

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The combined electrophysiological analysis further shows an overall reduction in functional expression of NR2A subunits along with relative increases in both, contribution of NR2B to the synaptic and extrasynaptic NMDAR-mediated currents and the magnitude of extrasynaptic NMDAR-mediated currents in lesioned HMNs

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Acknowledgements A.M.A

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