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The most striking recent piece of evidence came from a 2026 study published in Cell Metabolism [12], which found that semaglutide appeared to reverse cartilage damage in a mouse model of osteoarthritis, and crucially, this effect was independent of weight loss

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It also has cardiovascular benefits the heart uses L-carnitine to help fuel itself

MAJOR ADVERSE CARDIOVASCULAR EVENT REDUCTION Rybelsus is pending approval in October 2025 for MACE reduction in adults with T2D