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In this field, a crucial inflammatory factor, IL-1, was observed downregulated by Lactobacillus gasseri NK109 with the simultaneous upregulated expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of mice with cognitive impairment and depression induced by Escherichia coli K1, suggesting its alleviation in brain inflammation against neuropsychiatric disorders caused by bacterial infection [86]

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Synovial fibroblast-like cells, having a tumor-like appearance, secrete various proteases, including MMPs that degrade ECM components, mainly proteoglycans, and collagens, of articular cartilage in the affected joints

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Dixon S, Stockwell B

It also reduces adverse effects and damage to healthy tissues (17)

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