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After imputation, SNPs with a quality score ( R 2 ) below 0.90 were excluded, for PGS calculation SNPs with a MAF below 0.1% were filtered out

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So perhaps meeting recommended nutrient intakes remains achievable

Your only relevant comparison is to your own baseline

Treatment starts at 0.25 mg weekly for four weeks to improve tolerability, then typically increases to 0.5 mg, with further escalation to 1 mg or 2 mg if needed

The phase 2 trial showed that at 48 weeks, 92% of people taking 4mg lost at least 5% of their body weight