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In this study, the results of flow cytometry, immunofluorescence staining, RT-qPCR and ELISA assays demonstrated that GLP-1RAs could drive macrophage polarization towards the M2 type, thereby inhibiting the continuous development of synovitis

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The lack of additional interactions reduces its stability, and the absolute value of the binding free energy is relatively low

Despite this, the direction of effect was consistent across all four trials, with no evidence of increased risk in any individual study, supporting the coherence of the observed clinical signal

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LPS activates Toll-like receptors (TLRs), particularly TLR4, 72 triggering immune responses and cytokine release