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The ROS generated through radiolysis of cellular water and the free iron take part in the Fenton reaction-mediated lipid peroxidation of the plasma membrane and finally cell death through ferroptosis (Fig

The Reduction of Ferryl Myoglobin by Ergothioneine: a Novel Function for Ergothioneine

Supporting glutathione production through glycine supplementation may help manage this increased oxidative burden

Genomic Regulation: It resets the gene expression of the Ubiquitin-Proteasome System (UPS), enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes)

Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

It also produces favorable effects on the aging process