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Serious adverse events remain rare, and cardiovascular outcomes actually improve in patients with type 2 diabetes or obesity-related heart disease

Patrick OBrien at the retail analysts GlobalData said a successful sale of Boots would depend on whether Sycamore was prepared to accept a lower figure than the ludicrous valuation previously sought by Walgreens

This requirement is what distinguishes a medically necessary treatment from a general wellness purchase

In SURMOUNT-4 (Aronne et al., *JAMA* 2024), all patients ran an open-label phase reaching maximum tolerated dose (10 mg or 15 mg weekly) for 36 weeks, losing an average of 20.9% of body weight in that phase

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