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A healthier gut microbiome has been linked to improved production of appetite-regulating hormones, including GLP-1, which plays a role in satiety

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(2005) Mechanisms of acetohydroxyacid synthases

In elegant experiments, Perley and Kipnis in 1964 demonstrated that gastrointestinal, endocrine factors were responsible for the augmented insulin secretion (7) and also demonstrated that this mechanism was greatly impaired in non-insulin requiring maturity onset diabetes. The question then arose, which factors might be responsible, and the interest again turned toward the gastrointestinal hormones