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How GLP-1s Affect Body Composition GLP-1 medications work by mimicking glucagon-like peptide-1 (GLP-1), a hormone that plays a vital role in appetite regulation, blood sugar control, and digestion

In the causal process, the product of the a path quantifies the effect of independent variables (l-carnitine, betaine or DMG) on the mediator (TMAO), and the product of the b path quantifies the effect of the mediator (TMAO) on the dependent variable (NAFLD), controlling for independent variables (Reference Sobel19)

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This includes superoxide anions (O 2 -), hydroxyl radicals (OH), and hydrogen peroxide (H 2 O 2 )

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Specifically, 55.8% of patients in the semaglutide group had a decrease of at least 0.5 in ELF score compared to 25.5% in the placebo group