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SET7/9-mediated methylation of FoxO3 K270 prevented FoxO3 interaction with its target genes and prevented the transcriptional activation of FoxO3, indicating that the site of methylation regulates diverse biological processes

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In human myocytes from patients with obesity, GLP-1 alleviated obesity-induced reductions in muscle glucose uptake, but not in T2DM or healthy subject myocytes [106]