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It has been suggested that acyl glucuronides are intrinsically more reactive, being able to undergo rearrangement, via acyl migration (catalysed by hydroxide) to form 2-, 3- and 4-O positional isomers that are resistant to hydrolysis by -glucuronidases (Lo et al ., 2001)

Probucol's antioxidant effects make it a potential alternative therapy for improving atherosclerotic disease and effectively preventing carotid atherosclerosis progression in hypercholesterolemic patients (76)

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Additionally, it is advisable to monitor patients in the outpatient clinic, including regular lung assessments, as the lungs are the most common site of metastasis (42, 43)

McCoy AT, Benoist CC, Wright JW, Kawas LH, Bule-Ghogare JM, et al