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Multi-omics integration : transcriptomics, epigenomics, proteomics, and metabolomics to define subtypes and therapeutic windows

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Topspin version 3.0 (Bruker Biospin) was utilised for spectrometer control and data processing

Clinical trials demonstrate waist circumference reductions of approximately 9-10 cm with semaglutide and 14-18 cm with tirzepatide over treatment periods of 60-72 weeks

Temperature regulation changes are another side effect that surprises people

Results: Effect size for desire: 0.49 to 0.61 Effect size for distress reduction: 0.60 to 0.62 25% of treated patients versus 17% placebo achieved clinically meaningful desire increase 35% versus 31% achieved clinically meaningful distress reduction A 52-week open-label extension confirmed sustained efficacy and safety (PMC6819021, PMC6819023)