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The construction of animal models of iron overload ranging from high iron feed modeling to intraperitoneal administration of iron dextran has been reported and used in liver disease, cardiomyopathy, intracerebral hemorrhage, and hemochromatosis studies [50,51,52,53]

These collective findings demonstrate that VPA exposure induces systemic oxidative stress, characterized by concurrent antioxidant depletion (CAT, GSH-Px, GSH, SOD) and elevation of oxidative damage markers (MDA, T-NOS, NO)

DOI: 10.1007/s00213-024-06735-1

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J Plant Res 125:147153 Horemans N, Foyer CH, Asard H (2000) Transport and action of ascorbate at the plant plasma membrane