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Consistently, the livers of HFD-fed mice showed increased IKK--SSG levels, decreased IKK- phosphorylation, and suppressed NF-B activation when compared to these from control animals

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This can be observed in the modulation of BCL2 family protein levels by ROS, as heightened pro-apoptotic BAX and BAK1 levels accompanied by a decrease in anti-apoptotic BCL2 and BCL2-like 1 (BCL2L1/BCL-XL) expression are observed in squamous cell carcinoma cells [114]

PMID: 24944923

Parsaeian et al

Also, the zero-tolerance law is a civil violation, not a criminal one