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Am J Pediatr Hematol Oncol 1979;1:169-73

The Arg3 substitution is the critical functional modification because position 3 falls within the IGFBP binding domain, and the charge reversal from acidic glutamate to basic arginine disrupts the electrostatic complementarity required for high-affinity IGFBP interaction

Cantor JR, Sabatini DM

Of interest, MPO also associates with HDL via binding to ApoAI and PON1 in a ternary complex (282), so that the binding of MPO to HDL and subsequent generation of reactive oxygen species may account for the high levels of oxidized lipids carried by HDL

5 582

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity