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14 These widespread benefits stem from GH and IGF-1's systemic effects, leading to variable individual responses

Hepatic overexpression of SIRT6 inhibits intestinal cholesterol and fat absorption and reduces very low-density lipoprotein secretion, providing protection against steatohepatitis and atherosclerosis induced by a Western diet in Ldlr / mice [14]

Second, animal models can identify mechanistic patterns but may not reflect human physiology

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