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Bohn et al., 1999, 2002), but we prefer to use the term tolerance for such prolonged exposure, qualified as acute (several hours, Cox et al., 1968) or long-term (days) to avoid confounding the mechanisms of rapid desensitization of MOR with potentially different mechanisms of tolerance

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Under such conditions, the newly absorbed folate is not retained by the tissue and is released back into the systemic circulation, mostly as 5-methyl-THF

It remains an experimental compound without formal clinical guidelines for dosage or usage

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This dose has been extensively studied in combination with semaglutide under the investigational name CagriSema, achieving up to 22.7% weight reduction at 68 weeks in phase 3 trials [4]