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The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

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Key takeaways The maximum recommended daily dose of magnesium for adults is 420 mg for males and 350 mg for females

Per the blue line in the diagram here, oxidative stress was reduced even during the increased oxidative stress of reperfusion

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