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Ferroptosis has been proven to play a crucial role in OA progression, and blocking chondrocyte ferroptosis has been shown to alleviate OA symptoms 8

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5.5 Saponins Panaxadiol saponin metabolite (PDS-C), a bioactive cmetabolite isolated from total ginseng saponins (Dai et al., 2022), significantly improves liver function, hepatic steatosis, and lipid profiles in NAFLD mice by activating HO1 through the AMPK/Nrf2 signaling pathway while inhibiting NFB, thereby alleviating oxidative stress and inflammation to mitigate NAFLD (Mi et al., 2024)