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In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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Branched-chain-acylcarnitines are further oxidized in liver [37]

This overproduction can be triggered by UV exposure, inflammation, and hormonal changes all processes worsened by oxidative damage

Although accumulating evidence suggests that multiple bioactive constituents in GEB may confer protective effects against cerebral ischemia-reperfusion injury, the precise pharmacodynamic substances responsible for its therapeutic efficacy remain to be elucidated

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