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Gallbladder disease cholelithiasis and cholecystitis have been reported, associated with the drug and with rapid weight loss

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Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used to alleviate pain, can have adverse effects on gut health by disrupting the microbiome and causing inflammation

Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase

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Aged garlic extract (600-1,200 mg/day for 8-12 weeks) appears most effective because it stabilizes allicin and other bioactive compounds that relax blood vessels and improve nitric oxide availability