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Hold the syringe or pen at a 90-degree angle to the skin (unless instructed otherwise) and insert the needle swiftly and firmly into the skin at the chosen injection site

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It crosses the cell membrane and translocates to the nucleus under metabolic stress, where it regulates nuclear gene expression tied to glucose metabolism and oxidative capacity

Riool, M., de Breij, A., Kwakman, P., Schonkeren-Ravensbergen, E., de Boer, L., Cordfunke, R.A., et al., Biochem