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5-Amino-1MQ (5-amino-1-methylquinolinium) is the most studied inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme that acts as a metabolic brake in fat cells by depleting both SAM (S-adenosylmethionine) and NAD+ precursors

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However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine