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These results suggest that the interaction of the C-terminal region of HDIP1 with HDA19 is essential for the incorporation of HDIP1 into the HDAC complex in Arabidopsis plants, while the interaction of the second and third -helices of HDIP1 with SNLs seems to have an auxiliary role in its corporation into the complex

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To address this, researchers have developed stimuli-responsive PEG-shedding systems that react to tumor-specific cues such as acidic pH or elevated reductive potential, facilitating PEG detachment and enhancing cellular internalization [108, 109]

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