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The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

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Under conditions where antioxidant and iron-buffering systems are adequately engaged, NRF2 activation enhances GPX4, superoxide dismutase (SOD), and GSH levels, reduces lipid hydroperoxides, malondialdehyde (MDA), and ROS accumulation [118], and thereby suppresses ferroptotic cell death