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The neurotransmitter glutamate and its target, the N-methyl-D-aspartate receptor (NMDA-R), has a central role in fundamental brain functions including neural plasticity, neural network formation, and central nervous system repair, whereas excessive levels of glutamate are associated with excitotoxicity and neural degeneration [6]

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In vitro experiments demonstrated that cancer-associated adipocytes upregulate the hexosamine biosynthetic pathway (HBP), leading to O-GlcNAcylation and stabilization of the YAP protein

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