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Whereas JQ1 displaced the fluorescent JQ1 probe from BRD4 BD1 with similar half-maximal inhibitory concentration (IC 50 ) regardless of the E3 ligase presence, ZZ1-SO 2 H exhibited a 2.75-fold stronger suppressive effect (corresponding to an apparent cooperativity factor app ) in the presence of the YPEL5WDR26 module but not WDR26 alone

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