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Overall, the evidence from most controlled clinical trials for the sleep-promoting effects of valerian is inconclusive

doi: 10.1016/j.bbagen.2013.09.017 123 MasiAFortiniPKrokidisMGRomeoEFBasciettoCDe AngelisPet al

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Deficiency is virtually unknown among healthy people in Western countries, although diseases and poor lifestyle habits may increase the risk

Not by accident, mitochondria hold two to four times more NAD+ than other parts of the cell

Most findings are derived from in vitro models, underscoring the urgent need for robust in vivo validation in relevant preclinical models