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Treatment continuation requires demonstration of adequate response: For liraglutide: at least 5% weight loss after 12 weeks at the maintenance dose of 3.0 mg For semaglutide: assessment after approximately 3 months at the maintenance dose of 2.4 mg, with discontinuation if less than 5% weight loss achieved Private prescribing is available but costs vary by provider and medication

When blood glucose levels rise after eating, these medications enhance insulin release while simultaneously suppressing glucagon secretion from alpha cells

The risk seems higher in people who take the medicine for weight loss or fatty liver disease

Before the end of the shortage, he said he had "thousands" of patients on compounded products

Part of his hesitation: He dislikes needles, and all the drugs in this class that have been approved for weight loss come as shots that users give themselves once a week

These reactions usually appear within hours of injection and resolve within a few days