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2023 NEJM) showed semaglutide reduced major cardiovascular events by 20% in adults with overweight and prior cardiovascular disease, which is one reason labs matter for risk stratification What About the SELECT Trial and Cardiovascular Risk

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M., & Boeckxstaens, G

Through stimulation of pro-opiomelanocortin (POMC) neurons while simultaneously inhibiting neuropeptide Y/agouti-related peptide neurons in the arcuate nucleus, GLP-1 receptor agonism promotes satiety, reduces meal size, and decreases overall caloric intake [35]

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According to guideline, it is advised that the daily dose of PN should not exceed 200300 mg in order to prevent PN overdose, which can lead to nerve damage and motor dysfunction [13, 15]