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All three doses of orforglipron (6 mg, 12 mg, and 36 mg) studied in that trial met the primary and all key secondary endpoints by showing significant weight loss, meaningful A1C reductions, and improvements in cardiometabolic risk factors compared with placebo at 72 weeks

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However, much remains to be learned, and future studies will be crucial in confirming its involvement and potential as a therapeutic target or biomarker in PAH