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Dihexa's synaptogenic effects require activation of the c-Met receptor, as demonstrated by experiments using c-Met-specific short hairpin RNA (shRNA) which completely abolished Dihexa's capacity to induce spine formation

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This phenomenon refers to increased stimulation of insulin secretion by the pancreas after oral glucose ingestion compared to intravenous glucose infusion

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References Capezzuoli, T., Rossi, M., La Torre, F., Vannuccini, S