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1,2,6 Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense

Headaches: Some users may experience headaches after using the nasal spray

Goodacre AM, Clodi K, Grace C, Younes A, Cabanillas F, Andreeff M

Therefore, there is a substantial population of patients, numbering in the millions worldwide, living with disabling cardiogenic pain without hope of relief

Worth flagging: this was animal data