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People experiencing fatigue: B12 plays a role in energy production, and supplementation may help alleviate fatigue

[90] Setchell K, Borriello S, Hulme P, et al

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This metabolic reprogramming leads to the continuous production and accumulation of large amounts of lactate, which in turn causes acidification of the TME, promoting cancer cell growth, migration, and angiogenesis ( In addition, glucose transport plays a crucial role in regulating tumor glycolysis

Tajiri J, Higashi K, Morita M, Umeda T, Sato T: Studies of hypothyroidism in patients with high iodine intake

[3] Perovic, D., Kolenc, D., Bilic, V