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Contrast the times of events in mice to your estimated times of events in this patient with regard to: Duration of NAPQI formation Peak GSH depletion Onset of JNK activation Translocation of JNK to external mitochondrial membranes Mitochondrial DNA fragmentation Onset of MPT formation with release of AIF and Endo G Established necrosis Then repeat your estimates, but following a massive oral APAP ingestion

Diabetes Care 48 , S207S238 (2025)