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These changes are also related to improvements in quality of life, as they can alleviate common symptoms such as fatigue, jaundice, and gastrointestinal discomfort in patients with advanced liver disease [44]

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Small trials run in a single region, funded or supported by the maker, tend to report larger effects than big independent ones, partly because small studies that happen to land a positive result are the ones that get published while the null ones quietly disappear, and partly because looser blinding and outcome-grading let optimism leak into the numbers

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