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Effect of the Glucagon-Like peptide-1 receptor agonists semaglutide and liraglutide on kidney outcomes in patients with Type 2 Diabetes: pooled analysis of SUSTAIN 6 and LEADER

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As clinicians refine strategies for individualized care, GLP-1RAs are poised to play an increasingly prominent role in reducing cardiovascular events and improving long term outcomes across diverse patient populations

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68,69 Investigators have noted lower GSH concentrations to be associated with the combination of advanced age and increased risk of chronic diseases such as chronic renal failure, malignant disorders, diabetes, alcoholism, Parkinson's disease, and cataract formation

The benefit is dose-dependent and timing-sensitive: glutathione taken after acetaldehyde has already accumulated offers minimal relief because the oxidative cascade has already triggered inflammatory cytokine release