The receptor exists in two splice variants: the active GHS-R1a, which binds acylated ghrelin, and the truncated GHS-R1b, which is pharmacologically inactive but can modulate the activity of 1a through heterodimerisation
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Therefore, in production, cold-tolerant varieties should be selected as much as possible, and cold protection and resistance work should be carried out before and after the arrival of cold waves
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Nevertheless, overuse/abuse may be associated with unknown side effects given that it is often used in combination with other agents and at higher doses