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Es wird in jeder Zelle des Krpers produziert und erfllt drei essenzielle Funktionen: Antioxidativer Schutz: Glutathion neutralisiert freie Radikale und reaktive Sauerstoffspezies (ROS), bevor sie Zellmembranen, DNA und Proteine schdigen knnen

Additionally, activated microglia contribute to oxidative stress through the release of ROS, NO, and pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, inducing motor neuron death [254]

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Recent evidence both from animal and from human studies indicates that in failing myocardium, upregulation of Rac1 and p47 phox membrane protein expression, as well as increased Rac1-GTPase activity, may resemble the underlying mechanisms for increased oxidase activity and may represent a novel therapeutic target for statin therapy