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Finally, our subgroup analyses did not use multiple-comparison corrections and should be regarded as exploratory, particularly given the small number of events

In hepatocellular carcinoma (HCC) cells, post-translational activation of cystathionine -synthase (CBS) under TNF-induced oxidative stress increases TSS activity through a proteolytically cleaved and highly active form of CBS, increasing cystathionine and GSH production (102), which in turn promotes tumor progression and inhibits ferroptosis

Assessing all three may be key for risk stratification

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1,2 In 2021, an estimated 29.7 million adults in the United States (US) were diagnosed with diabetes, with an additional 8.7 to 9.8 million adults estimated to remain undiagnosed