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In contrast to AOD9604, hGH frag 176191 has not been studied in humans

The incidence of severe hypoglycemia in patients with type 2 diabetes was 5% at 26 weeks in patients receiving TOUJEO as part of a multiple daily injection regimen, and 1.0% and 0.9% respectively at 26 weeks in the two studies where patients received TOUJEO as part of a basal-insulin only regimen

In addition, PPAR was increased significantly by 2.84-fold ( p = 0.0041), suggesting the hypoglycemic mechanism of CB0313.1 may be associated with an attenuation of energy metabolic dysfunction and obesity (Fig

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Besides Vit B12 supplementation, additional measures could be considered such as Vit B9 supplementation and the use of COMT-I