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doi: 10.1016/j.ejphar.2025.177390 74 Rose-MartelMKulshreshthaGAhferom BerhaneNJodoinJHinckeMT

When administered by trained clinicians, NAD+ IV Therapy is generally well tolerated

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Early assessments revealed limited adherence to procedural pain guidelines and inconsistent sedation practices, and more recent studies confirm persistent gaps in pain assessment, analgesic administration and appropriate sedative use during invasive procedures ( Necrotizing enterocolitis (NEC) highlights the complexity of neonatal pain and sedation