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Authors acknowledge funding for the study by Dept

GLP-1 RAs ameliorate hepatic steatosis through improved insulin sensitivity, direct suppression of hepatic de novo lipogenesis through AMPK activation and SREBP-1c inhibition, and enhanced fatty acid oxidation through PPAR upregulation

8d, left), which led to a near-significant reduction in exendin-4-induced insulin secretion fold (Fig

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Neutral or highly hydrophobic peptides containing a high proportion of polar uncharged amino acids and/or hydrophobic amino acids should be dissolved in a small amount of an organic solvent such as DMSO, DMF, acetic acid, acetonitrile, methanol, propanol, or isopropanol and then diluted with water (or buffer) to the desired concentration