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Clinical trial NCT04050670 examined the relative bioavailability (AUC and Cmax) and tolerability of a single 5 mg tirzepatide dose injected subcutaneously into abdomen, thigh, and upper arm

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(2) It is engineered to favor growth hormone release rather than opioid activity, apparently by targeting ghrelin (growth hormone secretagogue) receptors instead of classical opioid receptors