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This remains an active area of research [5]

For a long time, the idea of activating the glucagon receptor seemed counterintuitive for metabolic control, as glucagon's primary role is to raise blood sugar by telling the liver to release glucose

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Nausea is one of the most frequently reported side effects associated with retatrutide in clinical trials to date, as documented in the Phase 2 randomised controlled trial published in the New England Journal of Medicine in June 2023 (Jastreboff et al., NEJM 2023)

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