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Their expression and responsiveness fluctuate across the 24-hour cycle, governed by the same hypothalamic-pituitary-adrenal axis that regulates cortisol
The right frequency is not something this guide can prescribe
This generally is not critical in testing male Caucasians, but it certainly is a problem in diagnosing some Caucasian females and blacks of both sexes, especially during the reticulocytosis following acute hemolysis
A shift in body fat, especially less around the midsection