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When they stand up, these lax blood vessels fail to constrict properly, allowing blood to pool in the lower extremities and depriving the brain of adequate oxygen

Nitric Oxide 116, 4764 10.1016/j.niox.2021.09.002 [DOI] [PMC free article] [PubMed] [Google Scholar] 70.Trujillo M

Therapeutic implications The biology argues against indiscriminate antioxidant loading. More promising are source- and compartment-targeted strategies (e.g., NOX isoform modulation, mitochondrial quality control, ER stress tuning), buffer re-balancing (GSH/thioredoxin systems), iron management to suppress Fenton chemistry and lifestyle interventions that reshape ROS tone without blunting adaptive signalling

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